Craving a cozy, protein-rich dinner that’s quick to prepare? This Spinach Chicken Casserole with Cream Cheese and Mozzarella is the ultimate answer. Featuring succulent chicken breasts, creamy layers of soft cheese, nutrient-dense spinach, and gooey melted mozzarella, this dish offers the perfect balance of comfort and health in every forkful. Whether you’re following a low-carb lifestyle or just need a filling dinner, this one-pan casserole is a must-try. With only 10 minutes of prep and no complicated steps, you’ll have a deliciously satisfying dinner on the table in under an hour!
Why You’ll Love This Recipe
This creamy spinach chicken bake checks every box: it’s low in carbs, keto-appropriate, and immensely gratifying. Juicy chicken mingles with a smooth cream cheese base and is topped with golden, bubbly mozzarella for a meal that feels indulgent yet fits healthy eating goals. It’s perfect for batch cooking or impressing guests. Plus, fresh spinach brings in both flavor and nutrition while making cleanup a breeze with its one-dish simplicity.
Ingredients
- 2 large chicken breasts, boneless and skinless, sliced horizontally into thin fillets
- 8 oz cream cheese, softened
- 2 cups fresh spinach, rinsed and drained
- 2 tbsp olive oil, divided
- 4 oz mozzarella cheese, shredded
- 3 garlic cloves, finely minced
- 1/2 tsp crushed red pepper flakes (optional)
- 1/2 tsp sea salt
- 1/2 tsp freshly ground black pepper
- 1/2 tsp Italian herb seasoning (optional)
How to Make Spinach Chicken Casserole
- Marinate the Chicken: Combine 1 tbsp olive oil, minced garlic, Italian seasoning, red pepper flakes, salt, and pepper in a Ziplock bag. Add the sliced chicken fillets, seal the bag, and gently knead to coat evenly. Let sit at room temperature for 10-15 minutes.
- Preheat the Oven: Place an oven rack in the center position and preheat to 400ºF (200ºC).
- Wilt the Spinach: Heat the remaining 1 tbsp olive oil in a skillet over medium heat. Add spinach and cook until just wilted. Remove from heat and set aside.
- Assemble the Casserole: Lay the marinated chicken fillets in a single layer in a baking dish. Evenly spread softened cream cheese on top, layer with wilted spinach, then sprinkle with shredded mozzarella.
- Bake: Bake uncovered for 20-30 minutes, until the chicken reaches an internal temperature of 165ºF (75ºC).
- Serve: Allow the casserole to cool for a few minutes before plating. Serve alongside roasted vegetables or cauliflower rice.
Helpful Tips
- Slice chicken uniformly for even baking.
- Bring cream cheese to room temperature for easier spreading.
- Enhance flavor by marinating chicken overnight.
- Broil for 2-3 minutes at the end for a golden cheese top.
Substitutions And Variations
- Protein: Use turkey cutlets or firm tofu instead of chicken.
- Cheese: Experiment with gouda, provolone, or parmesan.
- Greens: Substitute spinach with kale or arugula.
- Spices: Sprinkle in smoked paprika or cayenne for added heat.
Frequently Asked Questions
Can I use frozen spinach? Yes, just thaw it completely and squeeze out all the excess water before adding.
Is this recipe keto-friendly? Definitely—it’s high in healthy fats and protein, with minimal carbs.
Can I prepare this casserole in advance? Yes! Assemble it up to a day ahead and refrigerate until you’re ready to bake.
Storage Instructions
- Refrigeration: Keep leftovers in a sealed container in the fridge for up to 3 days.
- Freezing: Wrap the dish tightly and freeze for a maximum of 2 months. Defrost overnight in the fridge before reheating.
- Reheating: Warm in a 350ºF oven or microwave until thoroughly hot.
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Conclusion
This Spinach Chicken Casserole with Cream Cheese and Mozzarella brings together everything you want in a hearty, comforting meal—flavor, ease, and nutrition. Try it out for your next dinner, and don’t forget to share your experience in the comments! Looking for more cheesy chicken dinners? Browse our casserole collection for endless inspiration!
Print
Spinach Chicken Casserole with Cream Cheese and Mozzarella
- Total Time: 50 minutes
- Yield: 6 servings 1x
Description
Spinach Chicken Casserole with Cream Cheese and Mozzarella is a creamy, low-carb dinner made with tender chicken, sautéed spinach, and gooey cheese. This one-dish recipe is perfect for busy weeknights. Save and try it tonight!
Ingredients
2 large boneless, skinless chicken breasts, sliced horizontally into fillets
8 oz cream cheese, softened
2 cups fresh spinach, rinsed
2 tbsp olive oil, divided
4 oz shredded mozzarella cheese
3 garlic cloves, minced
1/2 tsp red pepper flakes (optional)
1/2 tsp salt
1/2 tsp black pepper
1/2 tsp Italian seasoning (optional)
Instructions
- Marinate the Chicken: Combine 1 tbsp olive oil, minced garlic, Italian seasoning, red pepper flakes, salt, and pepper in a Ziplock bag. Add the sliced chicken fillets, seal the bag, and gently knead to coat evenly. Let sit at room temperature for 10-15 minutes.
- Preheat the Oven: Place an oven rack in the center position and preheat to 400ºF (200ºC).
- Wilt the Spinach: Heat the remaining 1 tbsp olive oil in a skillet over medium heat. Add spinach and cook until just wilted. Remove from heat and set aside.
- Assemble the Casserole: Lay the marinated chicken fillets in a single layer in a baking dish. Evenly spread softened cream cheese on top, layer with wilted spinach, then sprinkle with shredded mozzarella.
- Bake: Bake uncovered for 20-30 minutes, until the chicken reaches an internal temperature of 165ºF (75ºC).
- Serve: Allow the casserole to cool for a few minutes before plating. Serve alongside roasted vegetables or cauliflower rice.
Notes
Use room-temp cream cheese for easy spreading.
Broil the last 2 minutes for a golden, bubbly cheese top.
Great with cauliflower rice or roasted veggies.
- Prep Time: 10 minutes Marinate Time: 10 minutes
- Cook Time: 30 minutes
- Category: Dinner, Casserole
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1 portion
- Calories: 320
- Sugar: 1g
- Carbohydrates: 3g
- Protein: 28g